Online checkout is currently available in the U.S. Contact us to make a purchase if you live in other countries!

Only 1 left in stock! Get 10 mL Disposable HPLC Lab Syringe (100 pcs) now — before anyone else!

Holiday notice: We will be off for the Chinese Lunar New Year Holiday between Feb 13th and 23th. Responses may be delayed. Welch US and India operate normally.

Visit WelchLab for a comprehensive collection of laboratory consumables, including glassware, plasticware, and more!

Knowledge Base

Pursuing Excellence in Pharmaceutical Quality Control: Best Practices and Insights for Laboratories

April 29, 2025

In this article, one of Welch’s long-term customer shares their practices and insights on pharmaceutical laboratory quality control in both HPLC and GC, along with their firsthand experience of Welch’s HPLC columns.

Read more
[Readers Insight] Why “Peak Area” is Used for Quantification in Chromatography

April 13, 2025

Peak area is the preferred metric for quantification in chromatography due to its consistency across variable peak shapes and resistance to signal distortion. Unlike peak height or volume, it offers reliable integration even with minor peak deformation or interference, making it the most robust choice in routine analysis.

Read more
[Readers Insight] Chromatographic Separation Strategies for Multi-Component Analysis

March 28, 2025

Mass spectrometry simplifies multi-component analysis, but chromatographic separation remains essential for challenging cases. This article explores enhancements in gradient elution, column selection, temperature, flow rate, and mobile phase composition for separation efficiency and resolution.

Read more
[Reader Insight] Optimizing Matrix Curve Quantification in Mass Spectrometry

December 20, 2024

In this article, the author explains matrix curve quantification in mass spectrometry, and offers strategies to minimize matrix effects and enhance accurate quantification.

Read more
[Reader Insight] Introduction to Common Derivatization Methods and Application Examples

December 12, 2024

This article explores key derivatization methods like methylation, amidation, and esterification, highlighting their principles, applications, and optimization strategies.

Read more
[Reader Insight] Why Are Chromatograms "Peak"-Shaped: A Guide for New Laboratory Analysts

December 4, 2024

Learn why chromatograms have the shape of peaks, understand their formation and what they reveal about analyte distribution and column efficiency.

Read more
[Reader Insight] Enhancing Analytical Sensitivity with Pre-column Derivatization in Mass Spectrometry

November 27, 2024

Pre-column derivatization enhances analytical sensitivity by improving chromatographic behavior, increasing ionization efficiency, and enabling optical detection for non-chromophoric compounds. This article explores how it reduces polarity, sharpens peaks, and enhances detection limits, making it a valuable tool for analyzing complex samples. By stabilizing target analytes, derivatization ensures more reliable qualitative and quantitative results in chromatography and mass spectrometry.

Read more
[Reader Insight] Matrix Effects in Mass Spectrometry Analysis: Causes and Solutions

November 21, 2024

Discover practical strategies to tackle matrix effects in mass spectrometry, from purification to isotopic standards, ensuring accurate and reliable results.

Read more
[Reader Insight] A Guide to Selective Columns for Isomer Separation

November 18, 2024

Explore specialized chromatography columns with shape selectivity and spatial interactions for effective isomer separation, including phenyl/PFP, amide, and C8 columns, etc.

Read more
[Reader Insight] A Brief Discussion on CMPA Method for Enantiomeric Separation: Some Practical Insights

November 13, 2024

Discover CMPA method insights for enantiomer separation using cyclodextrin additives, optimizing conditions with practical tips for efficient chromatographic performance.

Read more