Knowledge Base

Peak fronting is a common chromatographic anomaly characterized by a gradual leading edge and a steep trailing edge, often occurring during method development. This phenomenon stems from multiple causes, thus resolving it can be much more difficult. In this article, we discuss three primary sources of peak fronting and provide technical solutions to mitigate these effects and optimize chromatographic performance.

Learn why chromatograms have the shape of peaks, understand their formation and what they reveal about analyte distribution and column efficiency.