Knowledge Base
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The Four Pillars of Welch Materials ODS Columns
This article explores the fundamental qualities of ODS columns and examines four representative designs from Welch Materials. It reflects on long-standing misconceptions, practical challenges, and design considerations, offering chromatographers deeper insight into one of the most widely used tools in liquid chromatography. -
Preventing Hydrophobic Collapse: Demystifying AQ Columns
Struggling with weak retention of polar compounds in RP‑HPLC? Discover how Ultisil® AQ‑C18 delivers reliable performance under 100% aqueous conditions in this article. Enhance your analyses with stable retention and extended column life. -
The Shield of Preparative Liquid Chromatography: Prep In-Line Filter
Prep in-line filters play a crucial role in maintaining the performance and longevity of preparative chromatography systems. This article explores how these compact devices prevent clogging, reduce wear, and protect columns—acting as a reliable shield for your purification workflow. -
Advanchrom HIC-Butyl FAQ: Linker Stability, Sample Handling, Column Treatment…
This Q&A recap from our May 22 webinar covers essential questions on ADC analysis using Advanchrom HIC-Butyl columns, with expanded expert responses offering deeper insights into best practices and technical considerations. -
Welch Columns in the Spotlight: Shining Stars of the 2025 Edition of the Chinese Pharmacopoeia
Discover Welch HPLC columns featured in the 2025 Chinese Pharmacopoeia, with applications and specs for pharmaceutical analysis. -
Mastering the HPLC Autosampler: This Guide is All You Need
The HPLC autosampler is a key component for precise and efficient chromatography. This guide covers autosampler designs, injection methods, and essential maintenance practices to ensure accurate and reliable results. -
A Comprehensive Guide to Guard Columns and Pre-Columns
This guide explores key differences, functions, replacement guidelines, and selection criteria of guard columns and pre-columns (in-line filters) to help ensure optimal chromatographic performance and extended column lifespan.
