Knowledge Base

[Readers Insight] Matrix Effects in Mass Spectrometry: Why They Matter
by Shu Cheng
September 22, 2025

In this article, we explore further how matrix effects affects recovery results in mass spectrometry analyses by hindering preparation loss, and discuss when it should be corrected by using calibration curves prepared by blank matrices.

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[Reader Insights] Acidic or Basic? Read Analyte Structure First When Developing a Method
by Shu Cheng
September 11, 2025

In this article, we discuss how to read molecular structure to assess an analyte’s acidic or basic character and use that insight to design starting chromatographic methods. You will find practical, rule-based criteria, clear decision points for method setup, and a focused real-world example that illustrates structure-driven choices.

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[Readers Insight] The Starting Point in Method Development
by Shu Cheng
August 24, 2025

Method development often begins with uncertainty—especially when faced with unknown compounds and no literature guidance. This article examines a pharmacopoeial method as a case study, highlighting its chromatographic settings, analyzing potential limitations, and considering improvements. Through this, readers gain insight into the logical framework behind choosing starting conditions.

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[Readers Insight] Are You Choosing the Right Quantifier Ion for Mass Spectrometry?
by Shu Cheng
August 20, 2025

In this article, the author discusses the principles behind selecting quantifier ions in triple quadrupole mass spectrometry, with a case study to illustrate how ion choice impacts sensitivity and accuracy.

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[Readers Insight] Become an “Engineer”, Instead of an “Inspector”
by Shu Cheng
August 18, 2025

In this article, we dive into a lab analyst's journey from routine tester to engineer. It emphasizes asking “why”, seeking mentorship, designing experiments, iterative troubleshooting, and developing chromatographic expertise through persistent method development. The narrative offers practical encouragement for analysts aiming to deepen theoretical understanding, solve complex problems, and advance professionally.

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[Readers Insight] Why Do M-Shaped Peaks Occur?
by Shu Cheng
August 14, 2025

M-shaped peaks can puzzle even experienced chromatographers, appearing unexpectedly and resisting simple fixes. This article draws on expert insights to explore their possible origins and practical approaches, guiding analysts toward more reliable and consistent chromatographic results.

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Knowledge Base

[Readers Insight] Matrix Effects in Mass Spectrometry: Why They Matter

[Reader Insights] Acidic or Basic? Read Analyte Structure First When Developing a Method

[Readers Insight] The Starting Point in Method Development

[Readers Insight] Are You Choosing the Right Quantifier Ion for Mass Spectrometry?

[Readers Insight] Become an “Engineer”, Instead of an “Inspector”

[Readers Insight] Why Do M-Shaped Peaks Occur?