Holiday notice: We will be off for the Chinese Lunar New Year Holiday between Feb 13th and 23th. Responses may be delayed. Welch US and India operate normally.
In HPLC analysis, methanol and acetonitrile are the most common organic mobile phases. But have you ever thought about what exactly differentiates them? When should methanol be used and when acetonitrile? In this article, the author shares their thoughts on this matter.
![[Readers Insight] Choose Methanol or Acetonitrile? The Organic Mobile Phase in HPLC](//www.welch-us.com/cdn/shop/articles/1080_746151f5-d530-4722-b64b-4cc9cff7a1d3_535x.jpg?v=1765506053)
![[Readers Insight] Choose Methanol or Acetonitrile? The Organic Mobile Phase in HPLC](//www.welch-us.com/cdn/shop/articles/1080_746151f5-d530-4722-b64b-4cc9cff7a1d3_345x345@2x.jpg?v=1765506053)
![[Readers Insight] Choose Methanol or Acetonitrile? The Organic Mobile Phase in HPLC](http://www.welch-us.com/cdn/shop/articles/1080_746151f5-d530-4722-b64b-4cc9cff7a1d3_535x.jpg?v=1765506053)
![[Readers Insight] Choose Methanol or Acetonitrile? The Organic Mobile Phase in HPLC](http://www.welch-us.com/cdn/shop/articles/1080_746151f5-d530-4722-b64b-4cc9cff7a1d3_345x345@2x.jpg?v=1765506053)