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Formic acid is commonly seen added to the mobile phase in mass spectrometry methods, but have you wondered what specific role it plays, and can other acids substitute it? This article explains the role of formic acid in MS from the perspective of chemical reaction equilibrium thoroughly.
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![[Readers Insight] Why is Formic Acid Added to the Mobile Phase in Mass Spectrometry?](//www.welch-us.com/cdn/shop/articles/formic-acid-1080_285b53f7-6c39-44e1-98eb-566f7e73016d_345x345@2x.jpg?v=1765503777)
![[Readers Insight] Why is Formic Acid Added to the Mobile Phase in Mass Spectrometry?](http://www.welch-us.com/cdn/shop/articles/formic-acid-1080_285b53f7-6c39-44e1-98eb-566f7e73016d_535x.jpg?v=1765503777)
![[Readers Insight] Why is Formic Acid Added to the Mobile Phase in Mass Spectrometry?](http://www.welch-us.com/cdn/shop/articles/formic-acid-1080_285b53f7-6c39-44e1-98eb-566f7e73016d_345x345@2x.jpg?v=1765503777)