Knowledge Base

Choosing the right SPE cartridge from a dozen of candidates can be remarkably tough, yet it determines a large proportion of success in sample preparation. In this article, we discuss how to choose the SPE sorbent from sample matrix and analyte ionizability, and how to choose the cartridge size from the sample load.

Neotame is a food additive widely used in various food products. Due to its potential adverse effects, its use must comply with the maximum usage limits and permitted categories specified by relevant regulations. In this article, we introduce our solution using SPE-HPLC and SPE-LC-MS/MS, based on the Chinese national food safety standard GB 5009.247-2025.

Cereulide is an emetic toxin found in grains and dairy products that requires prevention and control. In this article, we present a method that quantifies cereulide in infant formula and rice cereal, using solid-phase extraction, UHPLC, and mass spectrometry.

Solid-Phase Extrtaction is a fast, easy and high-performance sample preparation technique widely used, but routine SPE runs can encounter recurring problems. This article summarizes typical causes and practical fixes for each SPE problem.