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Knowledge Base

A Premier Alkaloid: Nicotine and the Strategy for Developing Its Determination Method
by Gary Lee
October 9, 2025

Nicotine analysis is notoriously challenging due to its weak retention on conventional columns. This article shares a practical UHPLC-MS method using the Welch Ultisil HILIC Amphion II column, detailing the development approach, chromatographic conditions, and key advantages for reliable nicotine detection.

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