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    Unlocking the Key to ADC Drug Quality Control with Welch’s New HIC Columns!
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  5. Welch Materials Shines at CPHI Shanghai 2025: Exhibition Triumph and In-Depth Customer Symposium
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  • [Readers Insight] Is Retention Time Determined Solely by the Polarity of a Compound?

    [Readers Insight] Is Retention Time Determined Solely by the Polarity of a Compound?

    by Shu Cheng
    Have you ever thought about this question: In reversed-phase chromatography, does an earlier elution always mean the compound has higher polarity? Or rather — is retention time determined solely by the polarity of a compound? In this article, we explore what polarity is, why it acts as the primary factor affecting retention time, and what other factors are unneglectable.
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  • The Four Pillars of Welch Materials ODS Columns

    The Four Pillars of Welch Materials ODS Columns

    by Shu Cheng
    This article explores the fundamental qualities of ODS columns and examines four representative designs from Welch Materials. It reflects on long-standing misconceptions, practical challenges, and design considerations, offering chromatographers deeper insight into one of the most widely used tools in liquid chromatography.
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  • [Readers Insight] The Starting Point in Method Development

    [Readers Insight] The Starting Point in Method Development

    by Shu Cheng
    Method development often begins with uncertainty—especially when faced with unknown compounds and no literature guidance. This article examines a pharmacopoeial method as a case study, highlighting its chromatographic settings, analyzing potential limitations, and considering improvements. Through this, readers gain insight into the logical framework behind choosing starting conditions.
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  • Uncovering Overlooked Factors Behind Abnormal Baselines

    Uncovering Overlooked Factors Behind Abnormal Baselines

    by Shu Cheng
    A stable, flat baseline is essential for accurate HPLC analyses, yet analysts may grapple with noise and drift. This article explores key baseline disturbances—sawtooth patterns, pulsations, chaotic fluctuations, and drift—pinpoints their root causes, and offers precise remedies. A real-world case study demonstrates systematic troubleshooting to restore baseline integrity.
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  • Maintenance of HPLC Systems: Material Compatibility and Best Practices

    Maintenance of HPLC Systems: Material Compatibility and Best Practices

    by Shu Cheng
    Maintaining an HPLC system requires careful consideration of material compatibility, from 316L stainless steel pump heads to PEEK tubing. This article examines real‑world cases, compares flow‑path materials, and outlines practical cleaning and maintenance practices to safeguard analytical accuracy, prolong instrument life, minimize costly downtime, and prevent unexpected failures.
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