Knowledge Base

Supercritical fluid chromatography is gaining renewed attention in chiral analysis for its rapid separations, reduced organic solvent consumption, and strong chiral separation capabilities. In this article, we explore its principles, workflows, applications, and global market trends, and introduce Welch Materials' chiral analysis solution for both SFC and HPLC.

Chirality, the handedness in chemistry, can mean a significant difference between life-saver and toxicity. In this article, we not only explore how chiral HPLC separates enantiomers with its unique three-point interaction mechanism, but also briefly introduce five brand new chiral stationary phases in Blossmate Chiral series, greatly expanding Welch Materials' chiral chromatography solutions.

While synthetic intermediates are not themselves in the final API, their stereochemical purity affects product quality greatly. In this article, we present application notes of five typical synthetic intermediates, witnessing how Blossmate chiral columns successfully separate them from their enantiomers.

Chirality can mean the difference between medicine and catastrophe. In this article, we summarize the necessity of enantiomeric precision and explain how our Blossmate chiral columns offer flexible, MS-compatible solutions for analytical and preparative workflows, with chromatograms comparing our and competitor's column performances.