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  1. Unlocking the Key to ADC Drug Quality Control with Welch’s New HIC Columns!
    Unlocking the Key to ADC Drug Quality Control with Welch’s New HIC Columns!
    Apr 15, 2025
  2. New Ultisil BHS & CHS Packing Materials for Peptides Are Now Available!
    New Ultisil BHS & CHS Packing Materials for Peptides Are Now Available!
    May 06, 2025
  3. Introducing Advanchrom C18: Redefining HPLC Performance Through Innovation
    Introducing Advanchrom C18: Redefining HPLC Performance Through Innovation
    Aug 06, 2025
  4. Notice: Changes in HPLC Guard Cartridges Sell Units
    Notice: Changes in HPLC Guard Cartridges Sell Units
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  5. Welch Materials Shines at CPHI Shanghai 2025: Exhibition Triumph and In-Depth Customer Symposium
    Welch Materials Shines at CPHI Shanghai 2025: Exhibition Triumph and In-Depth Customer Symposium
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  • The Four Pillars of Welch Materials ODS Columns

    The Four Pillars of Welch Materials ODS Columns

    by Shu Cheng
    This article explores the fundamental qualities of ODS columns and examines four representative designs from Welch Materials. It reflects on long-standing misconceptions, practical challenges, and design considerations, offering chromatographers deeper insight into one of the most widely used tools in liquid chromatography.
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  • [Readers Insight] The Starting Point in Method Development

    [Readers Insight] The Starting Point in Method Development

    by Shu Cheng
    Method development often begins with uncertainty—especially when faced with unknown compounds and no literature guidance. This article examines a pharmacopoeial method as a case study, highlighting its chromatographic settings, analyzing potential limitations, and considering improvements. Through this, readers gain insight into the logical framework behind choosing starting conditions.
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  • [Readers Insight] Become an “Engineer”, Instead of an “Inspector”

    [Readers Insight] Become an “Engineer”, Instead of an “Inspector”

    by Shu Cheng
    In this article, we dive into a lab analyst's journey from routine tester to engineer. It emphasizes asking “why”, seeking mentorship, designing experiments, iterative troubleshooting, and developing chromatographic expertise through persistent method development. The narrative offers practical encouragement for analysts aiming to deepen theoretical understanding, solve complex problems, and advance professionally.
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  • [Readers Insight] Why Do M-Shaped Peaks Occur?

    [Readers Insight] Why Do M-Shaped Peaks Occur?

    by Shu Cheng
    M-shaped peaks can puzzle even experienced chromatographers, appearing unexpectedly and resisting simple fixes. This article draws on expert insights to explore their possible origins and practical approaches, guiding analysts toward more reliable and consistent chromatographic results.
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  • Agarose: A Versatile Packing Material for Protein Purification

    Agarose: A Versatile Packing Material for Protein Purification

    by Shu Cheng
    Agarose-based chromatographic media offer a compelling blend of biocompatibility, versatility, and affordability. By mastering the principles of agarose microsphere preparation and crosslinking, chromatographers can tailor supports to a vast array of protein purification challenges, ensuring high yield, purity, and process robustness.
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  • Mastering Gas Chromatography in 7 Comprehensive Steps!

    Mastering Gas Chromatography in 7 Comprehensive Steps!

    by Shu Cheng
    This article guides analysts in GC analyses through efficient sample preparation, instrument configuration, initial condition setup, separation optimization, qualitative identification using retention indices or GC–MS, quantitative analysis via internal standards or standard addition, rigorous method validation, ensuring accurate, precise, reproducible results across diverse unknown sample analyses consistently.
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  • Choosing Gas Chromatography Columns: Key Parameters

    Choosing Gas Chromatography Columns: Key Parameters

    by Shu Cheng
    In gas chromatography, column length, internal diameter, and film thickness critically determine efficiency, retention times, pressure requirements, and sample capacity. This article reviews how each parameter impacts chromatographic performance and provides practical selection guidelines—balancing resolution, analysis time, and cost—to help analysts choose optimal capillary columns for diverse applications.
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  • Uncovering Overlooked Factors Behind Abnormal Baselines

    Uncovering Overlooked Factors Behind Abnormal Baselines

    by Shu Cheng
    A stable, flat baseline is essential for accurate HPLC analyses, yet analysts may grapple with noise and drift. This article explores key baseline disturbances—sawtooth patterns, pulsations, chaotic fluctuations, and drift—pinpoints their root causes, and offers precise remedies. A real-world case study demonstrates systematic troubleshooting to restore baseline integrity.
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  • Maintenance of HPLC Systems: Material Compatibility and Best Practices

    Maintenance of HPLC Systems: Material Compatibility and Best Practices

    by Shu Cheng
    Maintaining an HPLC system requires careful consideration of material compatibility, from 316L stainless steel pump heads to PEEK tubing. This article examines real‑world cases, compares flow‑path materials, and outlines practical cleaning and maintenance practices to safeguard analytical accuracy, prolong instrument life, minimize costly downtime, and prevent unexpected failures.
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