Knowledge Base
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How to Distinguish Noise from Drift?
Learn how to identify and address baseline noise and drift in chromatography, understand their causes, and apply effective solutions for UV detectors. -
![[Reader Insight] Introduction to Common Derivatization Methods and Application Examples](//www.welch-us.com/cdn/shop/articles/derivatization-method-1080-1212_f33aec9a-97dd-4b57-8274-0c16be724f3f_345x345@2x.webp?v=1762501015)
[Reader Insight] Introduction to Common Derivatization Methods and Application Examples
This article explores key derivatization methods like methylation, amidation, and esterification, highlighting their principles, applications, and optimization strategies. -
What is the Dead Volume of A Column?
This article introduces dead volume in HPLC: its definition, calculation methods, and tips to reduce it for better peak shapes and chromatographic efficiency. -
Principles and Applications of Chaotropic Agents in the Analysis of Basic Compounds in RPLC
Learn about chaotropic agents in RPLC, their mechanisms, and benefits over ion-pair reagents, including improved retention, reproducibility, and column integrity. -
Unlocking the Potential of Derivatization Technology in HPLC Analysis
Discover how derivatization technology in HPLC boosts detection and separation performance, addressing analytical challenges with innovative techniques and real-world applications. -
Welch Xtimate Sugar Columns: Innovative Solutions for Carbohydrate Analysis
Welch Xtimate Sugar Columns offer precise carbohydrate separation via ion coordination exchange, with easy regeneration and protection from metal ion interference. -
![[Reader Insight] Why Are Chromatograms](//www.welch-us.com/cdn/shop/articles/peak-shaped-1080_535x.webp?v=1762502554)
![[Reader Insight] Why Are Chromatograms "Peak"-Shaped: A Guide for New Laboratory Analysts](//www.welch-us.com/cdn/shop/articles/peak-shaped-1080_345x345@2x.webp?v=1762502554)
[Reader Insight] Why Are Chromatograms "Peak"-Shaped: A Guide for New Laboratory Analysts
Learn why chromatograms have the shape of peaks, understand their formation and what they reveal about analyte distribution and column efficiency. -
Advanced Strategies for Retaining Polar Compounds in Chromatography: Case Studies and Practical Applications
Discover effective strategies and case studies for retaining polar compounds in chromatography, including column selection and practical applications. -
![[Reader Insight] A Guide to Selective Columns for Isomer Separation](//www.welch-us.com/cdn/shop/articles/selectivity-1080_a5bebdf8-ad89-4e8c-848d-f84a5656b179_345x345@2x.webp?v=1762503741)
[Reader Insight] A Guide to Selective Columns for Isomer Separation
Explore specialized chromatography columns with shape selectivity and spatial interactions for effective isomer separation, including phenyl/PFP, amide, and C8 columns, etc. -
![[Reader Insight] A Brief Discussion on CMPA Method for Enantiomeric Separation: Some Practical Insights](//www.welch-us.com/cdn/shop/articles/cmpa-1080_535x.webp?v=1762503901)
![[Reader Insight] A Brief Discussion on CMPA Method for Enantiomeric Separation: Some Practical Insights](//www.welch-us.com/cdn/shop/articles/cmpa-1080_345x345@2x.webp?v=1762503901)
[Reader Insight] A Brief Discussion on CMPA Method for Enantiomeric Separation: Some Practical Insights
Discover CMPA method insights for enantiomer separation using cyclodextrin additives, optimizing conditions with practical tips for efficient chromatographic performance. -
Understanding the C18 Columns: Activation, Maintenance, and Usage Tips
Discover best practices for C18 column activation and maintenance, including tips to achieve reliable and efficient analytical results.
![[Reader Insight] Introduction to Common Derivatization Methods and Application Examples](http://www.welch-us.com/cdn/shop/articles/derivatization-method-1080-1212_f33aec9a-97dd-4b57-8274-0c16be724f3f_345x345@2x.webp?v=1762501015)
![[Reader Insight] Why Are Chromatograms](http://www.welch-us.com/cdn/shop/articles/peak-shaped-1080_535x.webp?v=1762502554)
![[Reader Insight] Why Are Chromatograms "Peak"-Shaped: A Guide for New Laboratory Analysts](http://www.welch-us.com/cdn/shop/articles/peak-shaped-1080_345x345@2x.webp?v=1762502554)
![[Reader Insight] A Guide to Selective Columns for Isomer Separation](http://www.welch-us.com/cdn/shop/articles/selectivity-1080_a5bebdf8-ad89-4e8c-848d-f84a5656b179_345x345@2x.webp?v=1762503741)
![[Reader Insight] A Brief Discussion on CMPA Method for Enantiomeric Separation: Some Practical Insights](http://www.welch-us.com/cdn/shop/articles/cmpa-1080_535x.webp?v=1762503901)
![[Reader Insight] A Brief Discussion on CMPA Method for Enantiomeric Separation: Some Practical Insights](http://www.welch-us.com/cdn/shop/articles/cmpa-1080_345x345@2x.webp?v=1762503901)
