База знаний

Neotame is a food additive widely used in various food products. Due to its potential adverse effects, its use must comply with the maximum usage limits and permitted categories specified by relevant regulations. In this article, we introduce our solution using SPE-HPLC and SPE-LC-MS/MS, based on the Chinese national food safety standard GB 5009.247-2025.

Chirality, the handedness in chemistry, can mean a significant difference between life-saver and toxicity. In this article, we not only explore how chiral HPLC separates enantiomers with its unique three-point interaction mechanism, but also briefly introduce five brand new chiral stationary phases in Blossmate Chiral series, greatly expanding Welch Materials' chiral chromatography solutions.

The sugar column used in carbohydrate and sugar analysis has different operational precautions than other commonly used chromatographic columns. Many users, even after reading the product manual, still have difficulties on how to properly activate, use, and store them. In this article, we break down the details of using sugar columns

Cereulide is an emetic toxin found in grains and dairy products that requires prevention and control. In this article, we present a method that quantifies cereulide in infant formula and rice cereal, using solid-phase extraction, UHPLC, and mass spectrometry.

Chromatographic analysis for peptide drugs are important for ensuring product quality and safety. In this article, we introduce our solutions for peptide drug analysis, including the chiral analysis of protected amino acids, the determination of peptide related substances, the analysis of peptide aggregates by SEC, and the evaluation of amino acid ratios using the Welch Ultisil Amino Acid Method Kit.

In this article, we present solutions for the chromatographic analysis of biological samples from Welch Materials, covering SEC, RPLC, HIC, and ion exchange chromatography, with multiple applications of peptides, nucleic acids, antibodies, and proteins.

While synthetic intermediates are not themselves in the final API, their stereochemical purity affects product quality greatly. In this article, we present application notes of five typical synthetic intermediates, witnessing how Blossmate chiral columns successfully separate them from their enantiomers.

An HPLC column is a high-cost core consumable in laboratories, and improper handling and operational errors contribute to column degration. In this article, we introduce five foundational rules that safeguard your HPLC columns and explain the reason behind it.

More than half of APIs contain chiral centers, which may hinder drug activity if not separated. In this article, we use Blossmate chiral columns to separate five distinct APIs with their enantiomers, showcasing the columns' capability in such applications.

Isomer separation is one of the most challenging tasks in chromatography. In this article, we evaluate the chromatographic performance of three Welch Materials’ Ultisil stationary phases—PFP, Alk-C18, and XS-C18—on the separation of isomeric derivatives and analogs of antharaquinone.

Herbicides are an essential tool in weed management, and chirality greatly affects their efficacy. In this article, we explore the chiral separation of two herbicides: 2-(2-chlorophenoxy)propanoic acid and dimethenamid, using Welch Blossmate chiral columns.

In laboratory analysis, it is common to encounter scenarios where a column loses efficacy after being used in a different project, or where dozens of projects must be conducted by a small amount of columns. In this article, we explore the balance of dedicated and shared HPLC column use to ensure reliable analytical results while maximizing available resources.