More than half of APIs contain chiral centers, which may hinder drug activity if not separated. In this article, we use Blossmate chiral columns to separate five distinct APIs with their enantiomers, showcasing the columns' capability in such applications.
Herbicides are an essential tool in weed management, and chirality greatly affects their efficacy. In this article, we explore the chiral separation of two herbicides: 2-(2-chlorophenoxy)propanoic acid and dimethenamid, using Welch Blossmate chiral columns.
Alcohols and diols are among the most common functionalized intermediates in organic synthesis and pharmaceutical development, and chirality can influence their efficacy greatly. In this article, we introduce applications on the chiral separation of several typical alcohols and diol using Blossmate chiral columns.
Amino acids and their derivatives serve as fundamental building blocks in the synthesis of bioactive peptides and chiral drugs, and their chirality greatly affect the quality of the final product. In this article, we introduce the enantiomer separation of four different amino acid derivatives with Welch Blossmate chiral columns.
Achieving enantiomeric purity is vital for the clinical safety and efficacy. Among the most widely prescribed analgesics, NSAIDs presents a persistent analytical challenge due to the subtle structural variations between their R- and S-enantiomers. In this article, we present the chiral separation of three significant "profen" NSAIDs (flurbiprofen, tiaprofenic acid, and carprofen) with Welch's new Blossmate chiral columns.
Chirality can mean the difference between medicine and catastrophe. In this article, we summarize the necessity of enantiomeric precision and explain how our Blossmate chiral columns offer flexible, MS-compatible solutions for analytical and preparative workflows, with chromatograms comparing our and competitor's column performances.
