Introducing the WelPrep 2000 G2: The Next Evolution in Preparative HPLC

Introducing the WelPrep 2000 G2: The Next Evolution in Preparative HPLC

Introduction

As laboratory purification requirements continue to evolve, the demand for higher efficiency, precision, and environmental sustainability has become paramount. Building upon the robust foundation of its predecessor, Welch Materials is proud to announce the official release of the WelPrep 2000 G2 Preparative High-Performance Liquid Chromatography System.

This second-generation system is the result of deep technical refinement and a meticulous focus on user-centric applications. Designed to "unleash the pursuit of ultimate purification," the WelPrep 2000 G2 integrates advanced automation with a modular architecture to streamline workflows in both research and industrial production environments.

Core Innovations and Enhanced User Experience

The WelPrep 2000 G2 introduces several hardware and structural improvements aimed at optimizing daily laboratory operations:

  • Advanced Visual Interface: Both the solvent delivery pumps and the detectors are now equipped with 7.0-inch IPS high-definition LCD screens (1024 × 600 resolution). These displays support 65K colors and an 85° wide viewing angle, ensuring that instrument status and parameters are clearly visible from across the laboratory.
UV Detector with HD display
UV Detector with HD display
  • Optimized Structural Design: The manual injection valve features a novel drawer-style design, significantly simplifying the process of replacing sample loops and performing routine maintenance.
100 mL Pump
100 mL Pump
  • Versatile Modular Configuration: The system supports flexible arrangements to meet diverse purification scales. New features include a solvent recovery and recycling function to reduce operational costs and environmental impact.
  • Expanded Compatibility: The updated GalaChrom software is fully compatible with Sail1000 and HT1500L autosamplers, providing users with a broad range of configuration options.
GalaChrom configuration page
GalaChrom config page
  • Intelligent Control: The software provides a redesigned human-machine interface (HMI) available in multiple languages, providing intuitive display of parameter configurations and system status.

Technical Excellence: Key Module Specifications

High-Pressure Constant Flow Pump

Features advanced electronic pulsation compensation and multi-point flow calibration for high precision across the entire flow range. Pump heads are available in SS316L, PEEK, PTFE, or Hastelloy to ensure compatibility with diverse mobile phases. Includes integrated automatic detection of pressure exceptions for enhanced operational safety.

High-pressure Pump
High-pressure Pump

UV-Vis Detector

A dual-wavelength detection system offering high sensitivity and a wide linear range. Supports deuterium or tungsten lamps with multi-point wavelength calibration, time-programmable tasks, and a dedicated display. The universal sample cell is compatible with various optical pathlengths to meet diverse detection requirements.

UV-Vis Detector
UV-Vis Detector

21-Channel Autosampler

Supports continuous or repeated injections of multiple samples. Equipped with a 25 mL high-precision syringe and PTFE-coated peristaltic pump. Supports a wide injection range (0.1–25 mL), handles viscous samples, and includes an integrated bubble sensor for continuous, high-throughput processing. Features automated pre-injection liquid addition, derivatization, and dilution, as well as dedicated cleaning channels allowing for automated washing and draining.

21-Channel Autosampler
21-Channel Autosampler

16-Channel Fraction Collector

Upgraded to 16 channels with a new sample purging function to maximize recovery rates. Features low dead volume and minimal diffusion, supporting green lab initiatives via separate waste collection channels and solvent recovery. Designed for ease of maintenance with online cleaning and evacuation capabilities.

16-Channel Fraction Collector
16-Channel Fraction Collector

Recycling Preparative Module

Includes a built-in make-up pump for one-key automated filling, cleaning, and draining, and a unique Y-type buffer structure to stabilize pressure, minimize dead volume and sample diffusion. This module significantly improves resolution for complex separations without the need for additional columns or extra solvent consumption, saving preparation costs.

Recycling Preparative Module
Recycling Preparative Module

GalaChrom Chromatography Data System

An intuitive, multi-language (Chinese/English) workstation that integrates instrument control, data acquisition, and processing. Provides real-time visual monitoring of system status and ensures full compliance with GMP and FDA 21 CFR Part 11 regulations. Includes robust multi-level permission management and comprehensive audit trails to guarantee data integrity and traceability.

GalaChrom user interface
GalaChrom user interface

Flexible Integration for Modern Laboratories

A defining characteristic of the WelPrep 2000 G2 is its adaptability. While it functions as a seamless, integrated system, the combination of pumps, detectors, autosamplers, and recycling modules can be flexible based on specific application requirements. Notably, the system maintains backward compatibility with the 2022 Sail1000 and the original WelPrep 2000 models.

The 16-channel fraction collector and the autosampler also operate independently of the workstation when paired with other brands of Prep-HPLC systems, allowing laboratories to upgrade existing infrastructure with Welch Materials’ high-performance components while minimizing capital expenditure.

About Welch Materials

With over two decades of expertise in chromatography, Welch Materials continues to lead through innovation. The WelPrep 2000 G2 is a testament to this legacy, incorporating feedback from over 100 global users to deliver a system where efficiency, precision, and environmental consciousness are the new standard.

For further information and purchase inquiries, please e-mail us at info@welchmat.com.