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[Readers Insight] Why Are Ammonium Fluoride Added to the Mobile Phase in Modern LC-MS?
In recent high-impact publications on untargeted metabolomics, lipidomics, oligonucleotide therapeutics, and pesticide residue analysis, ammonium fluoride (NH4F) is a frequently encountered mobile phase additive. In this article, we will explore why it improves sensitivity in negative-mode LC-MS, and how it should be used to avoid compromising performance or damaging LC systems.
![[Readers Insight] Why Are Ammonium Fluoride Added to the Mobile Phase in Modern LC-MS?](http://www.welch-us.com/cdn/shop/articles/1080-1012_535x.jpg?v=1791857141)
![[Readers Insight] Why Are Ammonium Fluoride Added to the Mobile Phase in Modern LC-MS?](http://www.welch-us.com/cdn/shop/articles/1080-1012_345x345@2x.jpg?v=1791857141)