Solid-phase extraction, as an efficient sample preparation technique, has gained widespread use in various analytical laboratories. In recent years, there has been a growing number of newly developed solid-phase extraction materials, expanding the application areas of solid-phase extraction even further.

  • The expanded application of national and industry standard analysis methods:

Due to the excellent reproducibility and efficient extraction and purification capabilities of solid-phase extraction, it has been widely applied in the testing of national and industry standards both in the past and present. As solid-phase extraction technology continues to develop, it is expected to find even broader applications in the future.

  • The continuous expansion of application areas:

The application of solid-phase extraction has long surpassed sample preparation in laboratories. Solid-phase extraction technology has found extensive use in various fields including life sciences, industrial product domains, and inorganic detection areas.

  • Development of Novel Solid-Phase Extraction Materials:

The strong limitations posed by extreme pH conditions have hindered the application of conventional reversed-phase bonded silica solid-phase extraction materials. To address this issue, researchers have developed various types of solid-phase extraction materials, including high-polymer materials, molecularly imprinted polymers, restricted access media, immune-affinity materials, and more. The utilization of these new materials has further expanded the scope of solid-phase extraction technology applications.

  • Automation and High Throughput:

The evolution of solid-phase extraction has transitioned from simple laboratory column chromatography to industrial-scale production, and from manual operations to automation. Currently, an increasing number of automated instruments are emerging, leading to a broader application of solid-phase extraction technology in automation. In the future, a new generation of high-throughput automated solid-phase extraction instruments, tailored to the demands of various analytical fields, is expected to emerge.

  • Miniaturization and Simplification:

Miniaturization and simplification are trends in the development of sample preparation techniques, and solid-phase extraction is no exception. While classical solid-phase extraction techniques will continue to dominate for a considerable period, progress is always being made. For instance, building upon the fundamental principles of solid-phase extraction, AstraZeneca, a company based in Sweden, has introduced micro solid-phase extraction technology, also known as Packed Adsorbent Micro Extraction (PAME). To distinguish it from solid-phase microextraction (SPME), this technique is referred to as micro solid-phase extraction.

HTA4000E  SPE work station

  • Combining Multiple Sample Preparation Techniques:

Sample matrices exhibit diversity and complexity, making it impossible to address all sample preparation challenges with a single technique. The synergistic combination of two or more sample preparation techniques allows us to adeptly handle various types of samples. For example, the integration of techniques like accelerated solvent extraction and solid-phase extraction can be highly effective. Moreover, the fusion of multiple automated sample preparation instruments with such techniques represents a significant direction for the substantial advancement of solid-phase extraction technology.

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