In the process of using gas chromatography, partners often hear the word “solvent effect”. What exactly does “solvent effect” mean? About the solvent effect in gas chromatography, today will give you a brief overview and related solutions.
In gas chromatography, the boiling point of sample components is very important in the process of chromatographic separation. When we analyze some compounds with low boiling point, the peak time of sample components will be relatively shorter. Therefore, for these sample components with short peak time, they will overlap or cover the solvent peak in the sample solution. This phenomenon is the “solvent effect” in gas chromatography. So what are the reasons for this phenomenon and how to avoid “solvent effect” in the analysis process?
In the process of recording the chromatogram by the detector, when our solvent peak is seriously tailed and the peak width is large, it will be easier to affect the resolution with the target peak, so it is easier to cover some sample components that flow out earlier.
When the sample capacity of the chromatographic column is small: in order to avoid the overload of the chromatographic column and solve the solvent effect at the same time. We can also avoid solvent effect by changing the injection volume of sample solution. For example, adopt the split mode, increase the split ratio of gas chromatography, or select a smaller injection volume.
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