Filtration is a common step in our experiment, which can not only effectively prevent the blockage of frit and the damage of pump valve, but also avoid the peak shape variation and impurity peaks. Therefore, it is no denying that filtration plays a significant role in the protection of the instrument and the experimental results.
Whether it is a syringe filter or a circular microporous membrane, the first and most important attribute we have to concern is its material. For different ingredients to be filtered of samples, multiple filter membrane materials are available. Some filter membrane materials are introduced below.
Mixed cellulose (MCE): MCE materials have natural hydrophilicity and low protein binding capacity, mainly used for aqueous phase solution filtration, biochemical analysis filtration, especially for biological samples preparation and solution filtration.
Polyethersulfone (PES)：PES has features of hydrophilicity, low protein binding, high flow rate, high porosity and high throughput, suitable for the filtration of those viscous biological and cellular tissue samples.
Nylon: Nylon has good hydrophilicity and high protein binding, suitable for protein-free aqueous solution and organic solution. It can tolerate alcohol and DMSO, etc.
Polyvinylidene fluoride (PVDF): Polyvinylidene fluoride (PVDF): PVDF materials have good chemical stability and heat resistance, low protein binding capacity, suitable for general biofiltration. But it can not resist strong corrosive liquid filtration, acetone, DMSO, THF, DMF, dichloromethane, chloroform, etc.
Polytetrafluoroethylene (PTFE): PTFE solvent can be used to filter the organic solvents, water solutions and gases with resistance to strong acids, alkalis, organic solvents and oxidants, suitable for filtration of strongly corrosive solutions, organic solutions and gases.
Polypropylene (PP): PP is a natural hydrophobic filter medium with the characteristics of high-throughput and tolerance of high pressure. They are suitable for conventional filtration of organic solvents with high particle content.
Cellulose acetate (CA): CA materials are suitable for filtering aqueous solution, protein, low molecular alcohols and oils, characterized by high flow rate, thermal stability and low protein adsorption.
Glass fibre (GF) : GF materials can absorb more pollution than other cellulose or synthetic materials, suitable for conventional filtration of solutions with high particle content and viscosity. Besides, they can be used as prefiltration of solution which is hard to filter with high-throughput.
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