In recent years, there has been a continuous and vigorous effort in the pharmaceutical industry to explore innovative process technologies. From early-stage product development to modern separation and purification techniques, the pharmaceutical industry has undergone a profound transformation. Currently, separation and purification technologies have taken the lead in the market, significantly reducing drug evaluation time and shortening the overall drug development and research lifecycle. This advancement has sparked a wave of new transformations, earning accolades and recognition from a multitude of industry professionals.
In the field of pharmaceutical separation and purification, automated and efficient equipment such as automated samplers, preparative-scale dynamic axial compression columns, and fraction collectors have found widespread application. These technologies enable rapid and accurate attainment of desired results, providing a high-efficiency, cost-effective solution to organic component separation challenges encountered in the pharmaceutical industry.
HT1500L automatic sampler is a specialized instrument designed for high-throughput sample injection in workshops or laboratories. It can automatically extract samples with a high degree of accuracy, while being easy to install and maintain. This instrument effectively prevents residual contamination and diffusion of pollutants in samples, thereby saving both manpower and financial resources. As a result, the HT1500L automatic sampler is widely welcomed in various industries including laboratories, factories, and even hospitals.
| 45 positions (4 mL vials) 25 positions (40 mL vials) |
| Reproducibility (RSD – Relative Standard Deviation) | ≤0.25% | Maximum pressure tolerance: | 40MPa |
| Linearity: | ≥0.999 | Analysis time: | Analysis time: |
| Residual: | ≤0.01% | Cleaning modes | Pre-injection, post-injection |
| Sample depth and speed: | Adjustable | Data ports | USB and TTL |
| Injection mode | Full loop injection Supported | quantitative loops | 20 loops (40, 50, 100, 200, 500) μL and 1 (5, 10, 20) mL |
Furthermore, the Dynamic Axial Compression Column (DAC), abbreviated as DAC, has also found extensive application in the pharmaceutical industry. It is primarily utilized for the separation of high molecular weight substances. The advantage of Welch Materials’ DAC lies in its ability to effectively separate the desired substances according to customer specifications, minimizing contamination and losses while ensuring product quality.
Technical specifications for DAC50
Equipment model: WelPacker DAC50
| Serial number | Configuration | Parameters |
| 1 | Column specifications | 50*650mm |
| 2 | Maximum column height | 350mm |
| 3 | Column design pressure | ≤10Mpa |
| 4 | Cylinder design pressure | 150bar |
| 5 | Normal operating pressure of the system | 100bar |
| 6 | Roughness of the column inner wall | ≤0.2μm |
| 7 | Perforation size of the sieve plate | 3μm |
| 8 | Material for liquid interface | 316L stainless steel, PTFE, PEEK |
| 9 | Overpressure protection | Safety valve |
Technical specifications for DAC100
Equipment model: WelPacker DAC100
| Serial number | Configuration | Parameters |
| 1 | Column specifications | 100*650mm |
| 2 | Maximum column height | 350mm |
| 3 | Column design pressure | ≤10Mpa |
| 4 | Cylinder design pressure | 200bar |
| 5 | Normal operating pressure of the system | 100bar |
| 6 | Roughness of the column inner wall | ≤0.2μm |
| 7 | Perforation size of the sieve plate | 3μm |
| 8 | Material for liquid interface | 316L stainless steel, PTFE, PEEK |
| 9 | Overpressure protection | Safety valve |
Technical specifications for DAC150
Equipment model: WelPacker DAC150
| Serial number | Configuration | Parameters |
| 1 | Column specifications | 150*650mm |
| 2 | Maximum column height | 350mm |
| 3 | Column design pressure | ≤10Mpa |
| 4 | Cylinder design pressure | 300bar |
| 5 | Normal operating pressure of the system | 100bar |
| 6 | Roughness of the column inner wall | ≤0.2μm |
| 7 | Perforation size of the sieve plate | 3μm |
| 8 | Material for liquid interface | 316L stainless steel, PTFE, PEEK |
| 9 | Overpressure protection | Safety valve |
The fraction collector from Welch Materials has the capability to partition complex solutions into multiple units, thereby facilitating the collection of target substances. This functionality significantly enhances production efficiency while also accommodating more intricate experimental requirements.
120-channel automated fraction collector
| Capacity specifications: | 120 glass test tubes (15 mL) 88 centrifuge tubes (15 mL) 42 centrifuge tubes (50 mL) |
| Collection modes | Time, Peak value, Slope, Volume |
| Flow rate range | 0-200mL/min |
8-channel preparative fraction collector
| Capacity specifications: | 8-channel |
| Collection modes | Time, Peak value, Slope, Volume |
| Flow rate range | 0-1000mL/min |
In summary, it is precisely with the help of the advanced technologies mentioned above that the pharmaceutical industry has made such rapid progress in the field of separation and purification. These technologies have made the separation of organic components and active ingredients in bio-molecules more precise, fast, and efficient, providing a solid foundation for global drug safety and quality.
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