Propylene glycol is an important raw material of unsaturated polyester, epoxy resin and polyurethane resin. Propylene glycol has good viscosity and hygroscopicity, and is non-toxic. Therefore, it is widely used as hygroscopic agent, antifreeze agent, lubricant and solvent in food, medicine and cosmetics industry. In the food industry, propylene glycol reacts with fatty acids to form propylene glycol fatty acid esters, which are mainly used as food emulsifiers; Propylene glycol is an excellent solvent for condiments and pigments.

Propylene glycol is often used as the solvent, softener and excipient for manufacturing various ointments and ointments in the pharmaceutical industry. Due to its good mutual solubility with various spices, propylene glycol is also used as the solvent and softener of cosmetics. Propylene glycol is also used as tobacco humidifier, mildew inhibitor, lubricant of food processing equipment and solvent of food marking ink. The aqueous solution of propylene glycol is an effective antifreeze.

The method in this paper refers to the method under the determination of propylene glycol related substances in part IV of Chinese Pharmacopoeia 2020, and adopts Welch WM inowax (30M) × 0.32mm,1.0 μ m) The results of capillary column detection can meet the detection requirements.

Gas chromatographic conditions

Column: Welch WM inowax (30M) × 0.32mm,1.0 μ m)。

Flow rate: 1.5ml/min;

Temperature: The initial temperature shall be maintained at 80 ℃ for 3min, and the initial temperature shall be increased to 220 ℃ at 15 ℃ / min for 10min;

Injection port: 230 ℃;

Detector: FID 250 ℃;

Carrier gas: Nitrogen;

Injection volume: 1 μ L;

Split ratio: 5-1.


1. Mixed standard solution

2. Partial enlarged diagram of mixed standard solution


Referring to the method under the determination of related substances of propylene glycol in part IV of Chinese Pharmacopoeia 2020, a gas phase method for the analysis of related substances in propylene glycol was finally established. The results showed that Welch WM inowax (30M × 0.32mm,1.0 μ m) The resolution between adjacent peaks meets the requirements. This method can provide reference for the analysis of related substances in propylene glycol.

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