Determination of Related Substances in Amoxicillin and Clavulanate Potassium Granules by Xtiamte C18

Column Xtimate® C18(4.6×150mm,5μm) Mobile Phase Mobile phase A: 0.01 mol/L Potassium Dihydrogen Phosphate Solution (pH 6.0 adjusted with 2 mol/L Sodium Hydroxide Solution). Mobile phase B: 0.01mol/L potassium dihydrogen phosphate solution (adjusted with 2mol/L sodium hydroxide solution section pH6.0)/acetonitrile=20/80 Detection 230nm Temperature 35℃ Flow Rate 1.0ml/min Injection Volume 20 μL