Using ultra-high-purity silica gel matrix,High-quality chromatographic packing materials produced by unique patented technology
Excellent silica gel matrix ensures high mechanical strength of chromatographic packing materials
Packing materials will bear high mechanical pressure during filling and separation and purification, so the mechanical strength requirements for packing are usually higher than those for analysis.
The mechanical strength of the packing materials are an extremely important quality index, which is related to the life of the packing materials and the production process. Frequent filling times require very stable packing. If the mechanical strength is not enough, the packing will be broken, which will inevitably lead to an increase in column pressure and a decrease in column efficiency, which will affect performance.
The mechanical strength of the filler is an extremely important quality index, which is related to the life of the packing materials and the production process. Frequent filling times require very stable materials. If the mechanical strength is not enough, the packing materials will be broken, which will inevitably lead to an increase in column pressure and a decrease in column efficiency, which will affect performance. This requires high mechanical strength and strong bonding technology to extend the life of the packing materials, thereby improving the customer’s productivity and reducing the cost of the customer’s separation and purification.
Ultra-high purity fully porous spherical silica gel (purity>99.999%) Ensure high separation efficiency of chromatographic packing material
Uniform particle size distribution and pore size distribution ensure good separation efficiency and large sample volume.
Fine particles can increase the number of plates and resolution, but at the same time cause difficulty in column packing, requiring higher operating pressure and forming high column pressure; packing materials with narrow particle size distribution are easy to pack evenly, and a tighter and more stable column bed can be obtained. Reduce the eddy diffusion coefficient and improve the column efficiency; the narrow pore size distribution can increase the effective surface area and increase the sample loading. Therefore, uniform particle size distribution and pore size distribution are the guarantee for good separation effect and large sample loading.
Ultra-low metal content
The heavy metal content is an important criterion in the evaluation of the quality of the packing. If the heavy metal content is small quality, the non-specific adsorption of the packing to the separated substance will be low, and the peak shape is symmetrical. The heavy metal content of the silica gel packing selected by Welch Materials extremely low, all below 1 ppm, which is certified by a third-party testing agency. The heavy metal content limit is controlled from the source, which is the guarantee of the quality of the filler.
Sodium, magnesium, cadmium, chromium, mercury, copper, iron, calcium content
| Test items | Result (mg/kg) | Method detection limit (mg/kg) |
| Sodium | not detected | 1.0 |
| magnesium | not detected | 1.0 |
| cadmium | not detected | 1.0 |
| chromium | not detected | 1.0 |
| mercury | not detected | 1.0 |
| copper | not detected | 1.0 |
| iron | not detected | 1.0 |
| calcium | not detected | 1.0 |
Good batch-to-batch reproducibility
The chemical and mechanical stability, pore structure and specific surface area of the packing are highly reproducible between batches to ensure long-term, continuous and stable separation and purification production processes.
50 batches Ultisil® XB-C18 10μm 120Å batch-to-batch reproducibility
pH Stability Investigation
XB-C18 was tested with different brands of media under extreme conditions of pH 1.3 and 10. The test results are shown in the figure below:
Ultisil® XB-C18 packing is widely used in the preparation and separation of natural products, chemical raw materials and biologically active substances.
XB-C18:
- Antibiotic Purification
- Purification of organic synthesis products
- Biological fermentation purification
- Sample pretreatment
- Separation and purification of natural products
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